TANGO is a development organization guided by a constitution which outlines its structures and system of management and governance. The structures of TANGO are the following:

General Membership, is the supreme decision-making body comprising all members who meet once every year and elect a board every other year.

Board of Directors serves as the second-tier policy and decision-making body that also plays the key oversight function.

The management Team is responsible for the day-to-day operations of TANGO as it implements the decisions, policies and objectives of the General Membership and the Board. The Management Team conducts its business in line with operational tools for the management of human, material and financial resources including strictly conducting procurement and disbursement according to set guidelines. Furthermore, the TANGO has a set of policies on HIV, Gender, Children and the Environment to guide its actions and decisions around these issues based on sound ethics and values.

The Executive Director, together with the Program Manager and Accountant constitute the Senior Management Team.

The Finance Division is headed by the Accountant with a team of finance officers. The unit also oversees all other support staff. The finance Division is a crucial area as it deals with the management of the financial, human and material resources of TANGO in line with the TANGO Procedure Manual, Financial Manual and other management tools in place.

TANGO raises resources through membership subscriptions and support from donors including governments, international development organizations among other philanthropic individuals and organizations around the world.

The operations and management of TANGO are divided into a Program Division and a Finance Division. The overall head of the Secretariat is the Executive Director.

The Program Division is headed by the Program Manager who also doubles as the Deputy Executive Director (for administrative purposes) and comprises a team of program officers. The division serves as a think-tank and implementing unit of TANGO programs and projects. The quality and efficiency of the design, implementation and monitoring and evaluation of TANGO programs and projects lies with the Program Division.